Seroquel

Seroquel is a drug that is approved to treat schizophrenia in adults and adolescents aged 13-17 years and acute treatment of manic episodes associated with Bipolar I disorder in adults and pediatric patients 10-17 years of age. Seroquel has been linked to a number of side effects such as increased mortality in elderly patients with dementia-related psychosis, clinical worsening and suicide risk, Neuroleptic Malignant Syndrome (NMS), diabetes, hypoglycemia , hyperlipidemia, weight gain, Tardive Dyskinesia, orthostatic hypotension, seizures, hypothyroidism, and hyperprolactinemia. On April 11, 2005, the FDA issued an alert to healthcare professionals stating that the FDA has determined that patients with dementia-related psychosis treated with atypical (second generation) antipsychotic medications are at an increased risk of death compared to placebo. Based on the currently available data, FDA has requested that the package insert for Seroquel be revised to include a black box warning describing this risk and noting that this drug is not approved for psychosis or dementia.